Who Do You Love by Jennifer Weiner

Rachel and Andy are just eight when they first meet, but feel an instant connection, even though their backgrounds are very different.  Rachel has a bad heart and lives with her upper-middle class family in Florida, while Andy is bi-racial and calls a struggling neighborhood in Philadelphia home. Over the years, as they grow up, their emotional bond sometimes wavers--living in different cities and seeing each other occasionally. Still, Rachel and Andy haven't completely forgotten about each other, either. Will they eventually reunite and find happiness together?