Natalie Miller is riding high--living in New York City as a top aide to a senator. She's then diagnosed with breast cancer and her boyfriend, Ned, picks this as the time to announce he's breaking up with her. Now on her own, facing chemotherapy, she spends her days watching "The Price is Right" and trying to help with the senator's re-election campaign, even though she's supposed to be focusing on getting better. With a lot of time of her hands, she decides to track down her former boyfriends and try to find out why their relationships failed. She specifically thinks a lot about Jake, who's now the lead singer for a successful rock band. Natalie also finds herself spending time with her gorgeous gynecologist, Zach, who seems to be as attracted to her as she is to him. But is it really the best idea to start a relationship when you're battling for your life? The Department of Lost and Found is a sometimes funny, sometimes touching look at how a major event can change your outlook on the type of life you want to live.